Allergy & Immunology Billing

Allergy Billing That
Gets Immunotherapy Coded Right.

Allergy and immunology billing runs on precise per-test and per-dose coding — get the antigen preparation code, injection count, or same-day E&M modifier wrong, and clean claims turn into denials fast.

3
Immunotherapy codes to get right: 95165/95115/95117
Modifier 25
Required for same-day E&M billing
2
Skin testing methods that can't duplicate-bill same allergen
98.4%
Clean claim rate

Common Billing Challenges

Where Allergy & Immunology Billing Revenue Gets Lost

These are the six billing failure points we see most often in allergy and immunology practices — and the ones our team resolves systematically from day one.

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Immunotherapy Code Mix-Ups

95165 (antigen preparation), 95115 (single injection), and 95117 (two or more injections) are frequently confused, and the units billed don't match the doses actually prepared.

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Scratch + Intradermal Same-Day Duplication

Billing both percutaneous (95004) and intradermal (95024/95027) testing for the same allergen on the same day is treated as a duplicate by some payers.

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IgE Lab Testing Mixed With Skin Testing

Allergen-specific IgE testing (95076, 95079) is lab-based and billed differently from skin testing — mixing the two up is a coverage-rule error, not just a coding one.

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Outsourced Antigen Prep Billed as In-House

Billing 95165 for antigen preparation when a compounding pharmacy actually mixed it is a documented compliance error — if you didn't prepare it, you can't bill the professional component.

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Missing Modifier 25 on Injection-Day E&M

An E&M billed the same day as immunotherapy needs modifier -25 and its own independent documentation — using the immunotherapy note as the E&M note gets flagged by payers.

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Spirometry Bundling With Allergy Testing

In-office spirometry (94010) performed the same day as allergy testing needs independent medical necessity documentation, or payers bundle the two and deny one.

Key Procedure Codes

High-Value CPT Codes We Optimize for Your Practice

Our coders hold specialty-specific credentials and train continuously on the codes that drive the most revenue — and the most denials — in allergy and immunology.

CPT CodeDescriptionCommon Issue
95004Percutaneous (scratch/prick) allergy testingUnit-based — document each allergen and reaction
95024/95027Intradermal testing (single / sequential)Don't duplicate-bill same allergen as scratch testing same day
95076/95079Allergen-specific IgE (lab-based) testingBilled differently from skin testing — separate coverage rules
95165Antigen preparation, per doseOnly billable if your practice actually prepared it, not outsourced
95115/95117Immunotherapy injection (single / two or more)Confirm units match doses actually administered
94010SpirometryNeeds independent medical necessity documentation if billed same-day as allergy testing

Why Rcmaxis

Purpose-Built for Allergy & Immunology Billing

We're not a generalist billing service that added a specialty module. Our team is built around specialty-specific expertise.

01

Specialty-Credentialed Coders

Every coder on your account holds the specialty coding credential relevant to allergy and immunology — not a generic CPC only.

02

98.4% Clean Claim Rate

Built around the precise per-dose and per-test coding rules where a single modifier or unit-count error is usually the difference between a paid claim and a denial.

03

2-Week Onboarding

Full EHR integration, payer enrollment verification, and charge capture setup in 2 weeks — with zero disruption to your immunotherapy schedule.

04

Dedicated Account Manager

One point of contact who knows your practice, your payers, and your billing history — available for weekly calls and monthly performance reviews.

05

No Long-Term Contracts

Month-to-month engagement. We earn your business every month by improving your collections — not by locking you in.

06

Real-Time Dashboards

Live visibility into your collections, denial rate, aging AR, and payer performance — updated daily, reviewed monthly with your account team.

Common Questions About Allergy & Immunology Billing

Straight answers to what practices usually ask before they switch.

Technically yes, but many payers treat billing both percutaneous (95004) and intradermal (95024/95027) testing for the same allergen on the same day as a duplicate service. Check your specific payer's policy before billing both methods together, and document the clinical reason both were needed.
95165 covers the professional service of preparing the antigen — billed per dose, up to the total doses prepared. 95115 (single injection) and 95117 (two or more injections) cover the actual administration. You can only bill 95165 if your practice prepared the antigen; if a compounding pharmacy mixed it, billing 95165 as your own professional service is a compliance error.
Yes. Use modifier -25 on the E&M code, and the E&M documentation must stand on its own — a separate problem-focused note, not a reference back to the immunotherapy visit. Payers watch for E&M claims on injection days that reuse the immunotherapy note as their only support.
No. Subcutaneous immunotherapy (SCIT) has established CPT codes (95165, 95115, 95117). Sublingual immunotherapy (SLIT) doesn't have its own dedicated CPT code — most practices use an unlisted code or bill it under evaluation and management, and reimbursement is inconsistent across payers, with some not covering it at all. Check your payer contracts before offering SLIT as a covered service.

See what your allergy practice is leaving on the table.

Free revenue assessment for qualified practices. We audit your last 90 days of claims, identify every revenue leak, and show you a clear path to better collections — at no cost.

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Related Resources

Full Allergy & Immunology Coding GuideSpecialty Clinic BillingFree Revenue AssessmentReal Practice Results